Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 1, 1991Journal of VirologyOpen Access

Mutational analysis of the cellular receptor for poliovirus

View Full Paper
Ask AI
Bookmark
Share

Population

Mouse L cells

Design

Preclinical

Authors

MFMarion S. FreistadtRockefeller UniversityVRVincent R. RacanielloFox Chase Cancer Center

Discussion

Loading...

Member takes

Implication

PVR N-terminal domains mediate poliovirus entry; extends receptor mapping in animal models but leaves open human translation.

Structured PICO

P
Population
Mouse L cells
I
Intervention
Mutant cellular poliovirus receptor (PVR) cDNAs
O
Outcome
Ability to support poliovirus infection

Immunoglobulin-type domain 3 and the extreme carboxy terminus of the PVR are not required for viral receptor function, but sequences within the two amino-terminal domains contribute to the initiation of poliovirus infection.

Cite This Study

Freistadt et al. (1991) studied this question.

synapsesocial.com/papers/6a87cef6c61576201cfb0a38https://doi.org/10.1128/jvi.65.7.3873-3876.1991
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Heterogeneous Expression of Poliovirus Receptor-Related Proteins in Human Cells and Tissues1990 · 27 citations
  2. 2Heterogeneous expression of poliovirus receptor-related proteins in human cells and tissues.1990 · 65 citations
  3. 3Production of a Monoclonal Antibody against an Epitope on HeLa Cells that Is the Functional Poliovirus Binding Site1985 · 89 citations
  4. 4Structural requirements for C3d,g/Epstein-Barr virus receptor (CR2/CD21) ligand binding, internalization, and viral infection.1990 · 145 citations