What question did this study set out to answer?

To review the definitions, risk factors, and clinical strategies for preventing and managing autologous peripheral blood stem cell mobilization failure in patients with multiple myeloma.

October 5, 2017Journal of Clinical Apheresis

Current strategies for the management of autologous peripheral blood stem cell mobilization failures in patients with multiple myeloma

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Authors

UŞUğur ŞahinAnkara University TDTaner DemirerAnkara University

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Implication

Narrative review outlines risk factors and definitions for stem cell mobilization failure in multiple myeloma, highlighting strategies to optimize collection yields for transplantation.

Key Points

To review the definitions, risk factors, and clinical strategies for preventing and managing autologous peripheral blood stem cell mobilization failure in patients with multiple myeloma.
Synthesized clinical criteria defining proven and predicted poor stem cell mobilizers during autologous transplantation workups.
Evaluated patient demographics, prior induction therapies, and disease-related factors impacting target CD34+ cell collection yields.
Proven poor mobilization is characterized by peak peripheral blood CD34+ counts <20/µL following adequate G-CSF stimulation or yields <2.0 × 10^6 CD34+ cells/kg after three apheresis sessions.
Predicted poor mobilization is identified by prior collection failure, previous extensive radiotherapy, or presenting with at least two risk factors such as age >65 years, refractory disease, extensive marrow involvement, or >2 lines of chemotherapy.

Cite This Study

Şahin et al. (2017) studied this question.

synapsesocial.com/papers/6a87cf44f762332bf8fe7f9c https://doi.org/10.1002/jca.21591

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Implication

Narrative review outlines risk factors and definitions for stem cell mobilization failure in multiple myeloma, highlighting strategies to optimize collection yields for transplantation.

Current strategies for the management of autologous peripheral blood stem cell mobilization failures in patients with multiple myeloma

Discussion

Member takes

Implication

Key Points

Cite This Study

Current strategies for the management of autologous peripheral blood stem cell mobilization failures in patients with multiple myeloma

Discussion

Member takes

Implication

Key Points

Cite This Study

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