Why the study?
Exercise performance can be limited by muscle fatigue and pain transmitted by muscle afferents, and it has been proposed that exercise training abrogates these negative feedback signals.
Exercise training may prevent immediate exercise-induced muscle pain by downregulating acid-sensing ion channels (ASICs) in sensory neurons.
ASIC downregulation may mediate training-induced pain relief; leaves open whether targeting ASICs enhances human exercise capacity.
Exercise performance can be limited by the sensations of muscle fatigue and pain transmitted by muscle afferents. It has been proposed that exercise training abrogates these negative feedback signals. We found that acid-sensing ion channels (ASICs) are required for immediate exercise-induced muscle pain (IEIP). Moreover, exercise training prevented IEIP and was correlated with downregulation of ASICs in sensory neurons.
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Khataei et al. (2020) studied this question.
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