Two new and four known polyphenolics obtained as new cell-cycle inhibitors from Rubus aleaefolius poir

Two new polyphenolics, rubuphenol (1) and sanguiin H-2 ethyl ester (2), were isolated together with ellagic acid (3), ethyl gallate (4), 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose (5) and 1,2,3,6-tetra-O-galloyl-beta-D-glucopyranose (6) as new cell-cycle inhibitors from Rubus aleaefolius by bioassay-guided separation procedure and the structures of 1 and 2 were elucidated by spectroscopic method. Compounds 1-6 inhibited the cell cycle progression of tsFT210 cells at the G0/G1 phase with the MIC values of 14.6 microM (1), 22.1 microM (2), 10.3 microM (3), 7.8 microM (4), 7.9 microM (5) and 6.6 microM (6).