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Investigate the regulatory role of gonadotropin-inhibitory hormone (GnIH)-3 in coordinating reproductive hormone secretion, sexual behavior, food intake, and energy expenditure across mammalian species.

January 1, 2012Neuroendocrinology

Gonadotropin-Inhibitory Hormone Is a Hypothalamic Peptide That Provides a Molecular Switch between Reproduction and Feeding

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Investigate the regulatory role of gonadotropin-inhibitory hormone (GnIH)-3 in coordinating reproductive hormone secretion, sexual behavior, food intake, and energy expenditure across mammalian species.
Examined GnIH gene expression in ewes via in situ hybridization, and infused intravenous GnIH-3 following estradiol benzoate administration to test for luteinizing hormone surge blockade.
Administered intracerebroventricular GnIH-3 infusions to evaluate sexual behavior in sheep, mice, and cynomolgus monkeys, as well as food intake and energy expenditure in sheep and rats.
Assessed neuronal activation by quantifying Fos protein expression in orexigenic and anorexigenic neurons using immunohistochemistry.
GnIH gene expression decreased during the preovulatory period in ewes, and intravenous GnIH-3 infusion successfully blocked the positive feedback estrogen-induced luteinizing hormone surge.
Central GnIH-3 infusion stimulated food intake across species and increased Fos expression in orexigenic neurons without altering energy expenditure or male and female sexual behavior.

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Implication

Preclinical study demonstrates that gonadotropin-inhibitory hormone suppresses luteinizing hormone surges while increasing food intake in mammals, indicating a coordinated metabolic-reproductive...

Cite This Study

Clarke et al. (2012) studied this question.

synapsesocial.com/papers/6a87d1403bdf89560ead32cd https://doi.org/10.1159/000332822

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Implication

Preclinical study demonstrates that gonadotropin-inhibitory hormone suppresses luteinizing hormone surges while increasing food intake in mammals, indicating a coordinated metabolic-reproductive...

Gonadotropin-Inhibitory Hormone Is a Hypothalamic Peptide That Provides a Molecular Switch between Reproduction and Feeding

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Cite This Study

Gonadotropin-Inhibitory Hormone Is a Hypothalamic Peptide That Provides a Molecular Switch between Reproduction and Feeding

Key Points

Discussion

Implication

Cite This Study

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