What question did this study set out to answer?

To synthesize current scientific understanding of tight junction molecular components, their regulation under physiological and pathological states, and their modulators in the blood-brain barrier.

June 12, 2012CNS Neuroscience & TherapeuticsOpen Access

Tight Junction in Blood‐Brain Barrier: An Overview of Structure, Regulation, and Regulator Substances

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To synthesize current scientific understanding of tight junction molecular components, their regulation under physiological and pathological states, and their modulators in the blood-brain barrier.
Synthesized molecular and physiological findings concerning the protein architecture of tight junctions at the blood-brain barrier.
Evaluated cellular responses and permeability alterations occurring during stimulation and pathological disruption of tight junctions.
Tight junction complexes between adjacent brain endothelial cells establish a specialized physical seal that strictly limits paracellular permeability into the central nervous system.
Pathological conditions and external stimuli trigger signaling cascades that alter tight junction protein assemblies, compromising barrier integrity and homeostasis.
Distinct regulatory molecules act as modulators of tight junction assembly, offering mechanistic targets to enhance barrier function or facilitate central nervous system drug delivery.

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Implication

Review details tight junction molecular structure and regulation in the blood-brain barrier, highlighting therapeutic mechanisms for central nervous system stability.

Cite This Study

Liu et al. (2012) studied this question.

synapsesocial.com/papers/6a87d2c7a95224e440015568 https://doi.org/10.1111/j.1755-5949.2012.00340.x

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Implication

Review details tight junction molecular structure and regulation in the blood-brain barrier, highlighting therapeutic mechanisms for central nervous system stability.

Tight Junction in Blood‐Brain Barrier: An Overview of Structure, Regulation, and Regulator Substances

Key Points

Discussion

Implication

Cite This Study

Tight Junction in Blood‐Brain Barrier: An Overview of Structure, Regulation, and Regulator Substances

Key Points

Discussion

Implication

Cite This Study

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