What question did this study set out to answer?

To determine whether alterations in circulating endothelin-1, circulating nitric oxide, and cardiac nitric oxide correlate with the development of doxorubicin-induced cardiotoxicity.

September 1, 2001Pharmacology & Toxicology

Increased Plasma Endothelin-1 and Cardiac Nitric Oxide during Doxorubicin-Induced Cardiomyopathy

View Full Paper

Ask AI

Bookmark

Authors

MSMohamed M. Sayed‐AhmedCairo University MKMahmoud M. KhattabMohammed V University MGMohamed Z. GadDepartment of Biotechnology

Discussion

Member takes

Implication

May support endothelin-1 as a biomarker in rat models; leaves open clinical monitoring or targeting in patients.

Key Points

To determine whether alterations in circulating endothelin-1, circulating nitric oxide, and cardiac nitric oxide correlate with the development of doxorubicin-induced cardiotoxicity.
Administered doxorubicin intraperitoneally to male rats across cumulative doses of 10, 15, 20, and 25 mg/kg (given at 5 mg/kg every other day), as a single 20 mg/kg dose, or as a saline control.
Assayed plasma endothelin-1, plasma nitric oxide, myocardial nitric oxide, and serum injury enzymes (lactate dehydrogenase and creatine phosphokinase) 24 hours after final dosing.
Doxorubicin significantly increased plasma endothelin-1 by 85%, 76%, and 97% at cumulative doses of 10, 15, and 20 mg/kg, respectively, whereas circulating plasma nitric oxide remained unchanged.
Cardiac tissue nitric oxide rose non-dose-dependently with a peak increase of 81% at a cumulative dose of 10 mg/kg, coinciding with dose-dependent rises in serum lactate dehydrogenase and creatine phosphokinase.
A single acute dose of 20 mg/kg doxorubicin also significantly elevated both plasma endothelin-1 and cardiac nitric oxide levels within 24 hours.

Cite This Study

Sayed‐Ahmed et al. (2001) studied this question.

synapsesocial.com/papers/6a87d4698a3f93fc1e0625a8 https://doi.org/10.1034/j.1600-0773.2001.d01-148.x

View Full Paper

Ask AI

Bookmark

Increased Plasma Endothelin-1 and Cardiac Nitric Oxide during Doxorubicin-Induced Cardiomyopathy

Discussion

Member takes

Implication

Key Points

Cite This Study

Increased Plasma Endothelin-1 and Cardiac Nitric Oxide during Doxorubicin-Induced Cardiomyopathy

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider