Why the study?
Clinical and genetic variants associated with early-onset cardiac toxicity at a low cumulative dose of chemotherapy drugs in breast cancer had not been fully identified.
Do clinical factors and genetic variants predict early-onset cardiac toxicity in breast cancer patients receiving adjuvant chemotherapy?
Do clinical factors and genetic variants predict early-onset cardiac toxicity in breast cancer patients receiving adjuvant chemotherapy?
A prediction model combining clinical factors and genetic susceptibility (such as the SLC28A3 rs885004 GG genotype) improves the prediction of early-onset cardiac toxicity in breast cancer patients undergoing adjuvant chemotherapy.
Anthracycline use and SLC28A3 GG genotype were associated with cardiotoxicity; leaves open validation of genetic risk models before clinical adoption.
Aim: To identify clinical and genetic variants associated with early-onset cardiac toxicity with a low cumulative dose of chemotherapy drugs in breast cancer. Methods: A total of 388 recruited patients completed routine blood, liver and kidney function, D-dimer, troponin T, brain natriuretic peptide (BNP) or N-terminal prohormone of BNP, ECG and echocardiography tests before and after adjuvant chemotherapy. 25 single-nucleotide polymorphisms (SNPs) were tested. Results: A total of 277 adjuvant chemotherapy-related cardiac toxicity events were recorded in 180 patients (46.4%). Anthracycline-containing chemotherapy (odds ratio: 1.848; 95% CI: 1.135–3.008; p = 0.014) and the SLC28A3 rs885004 GG genotype (odds ratio: 2.034; 95% CI: 1.189–3.479; p = 0.010) were found to be associated with overall cardiac toxicity. The final predictive risk model consisting of clinical risk factors and SNPs was better than SNP alone (p = 0.006) or clinical risk factor alone (p = 0.065). Conclusion: On the basis of clinical factors, a prediction model with genetic susceptibility factors can better predict early-onset cardiac toxicity.
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Liu et al. (2022) studied this question.
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