Prolongation of the QT Interval and Ventricular Tachycardia in Patients Treated with Arsenic Trioxide for Acute Promyelocytic Leukemia

Letters6 November 2001Prolongation of the QT Interval and Ventricular Tachycardia in Patients Treated with Arsenic Trioxide for Acute Promyelocytic LeukemiaJean T. Barbey, MD and Steven Soignet, MDJean T. Barbey, MDGeorgetown University; Washington, DC 20007 (Barbey)Memorial Sloan-Kettering Cancer Center; New York, NY 10021 (Soignet) and Steven Soignet, MDGeorgetown University; Washington, DC 20007 (Barbey)Memorial Sloan-Kettering Cancer Center; New York, NY 10021 (Soignet)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-9-200111060-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:While we fully concur with Ohnishi and colleagues (1) that patients receiving arsenic trioxide need close monitoring, we cannot endorse the strategy they suggest to minimize the cardiac risks associated with arsenic therapy.The authors state that asymptomatic monomorphic ventricular tachycardia developed in 4 of 8 patients during arsenic therapy and was associated with a moderately prolonged QT interval. In fact, 2 of these patients had known preexisting ventricular arrhythmias. For the 2 other patients, it seems difficult in the absence of prolonged baseline recordings to determine whether nonsustained asymptomatic ventricular arrhythmias truly developed de novo or ...References1. Ohnishi K, Yoshida H, Shigeno K, Nakamura S, Fujisawa S, Naito K, et al . Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia. Ann Intern Med. 2000;133:881-5. [PMID: 11103058] LinkGoogle Scholar2. Echt DS, Liebson PR, Mitchell LB, Peters RW, Obias-Manno D, Barker AH, et al . Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial. N Engl J Med. 1991;324:781-8. [PMID: 1900101] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Jean T. Barbey, MD; Steven Soignet, MDAffiliations: Georgetown University; Washington, DC 20007 (Barbey)Memorial Sloan-Kettering Cancer Center; New York, NY 10021 (Soignet)Disclaimer: Both authors are paid consultants to Cell Therapeutics, Inc., the manufacturer of arsenic trioxide, and have participated in trials evaluating arsenic. 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