Reversal of Runner's Bradycardia with Training Overstress

OBJECTIVE: To elicit a criterion elevation (> 10%) in resting heart rate (HR) with training overstress, and subsequently test the hypothesis that such "reversed bradycardia" (RB) negatively affects running performance. DESIGN: Prospective before-and-after intervention with a comparison group. SETTING: General community. PARTICIPANTS: 21 healthy male marathon runners. INTERVENTION: Voluntary doubling of training miles on 14 consecutive days. MAIN OUTCOME MEASURES: Left ventricular (LV) function by echocardiography, HR, and plasma epinephrine (PE) at rest and during submaximal exercise, and 15 km road run performance. RESULTS: Two days after the training overstress, 12 runners met the criterion (RB group), showing an average elevation in resting HR of 16% (range: 11 to 23%). The RB group also exhibited hyperkinetic LV shortening (p < 0.05), elevated exercise HR (p < 0.001), increased PE at rest and during exercise (p < 0.05), and reduced 15 km performance (p < 0.05). The other nine runners who maintained a stable resting HR during the intervention showed no significant outcome changes. CONCLUSIONS: In addition to muscular overuse, heightened sympathetic drive likely contributed to the observed reversal of bradycardia. The development of this stress-related cardiac perturbation was associated with a decrement in running performance, confirming the hypothesis.