Intensive vs. standard blood pressure control and vascular procedures: insights from the Systolic Blood Pressure Intervention Trial (SPRINT)

Trial Registration: SPRINT (Systolic Blood Pressure Intervention Trial); ClinicalTrials.gov Identifier: NCT01206062, https://clinicaltrials.gov/ct2/show/NCT01206062. Hypertension is a risk factor for both the occurrence and rupture of abdominal aortic aneurysms, is present in most individuals with acute aortic dissection, and has been linked with an increased risk of peripheral artery disease (PAD).1–3 Limited data are available to inform whether lower blood pressure (BP) treatment targets affect the risk of peripheral vascular events. We examined the risk of vascular procedures (as a proxy of progression of PAD) with intensive vs. standard BP control in The Systolic Blood Pressure Intervention Trial (SPRINT).4 SPRINT was a randomized, controlled, open-label trial in...