Why the study?
Do ischemia, hypoxia, or increased workload alter mitochondrial F1-ATPase activity in canine myocardium?
Population
Canine myocardium (submitochondrial particles prepared from biopsy samples)
Comparison
Global ischemia, hypoxia, phenylephrine… vs Baseline/normal myocardium
Design
Preclinical
Authors
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Preclinical canine data should not alter ischemia management; leaves open F1-ATPase regulation of myocardial oxidative phosphorylation.
Do ischemia, hypoxia, or increased workload alter mitochondrial F1-ATPase activity in canine myocardium?
Changes in F1-ATPase activity during ischemia and increased workloads suggest its role in regulating myocardial oxidative phosphorylation.
Scholz et al. (1994) studied this question.
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