Population
Live mammalian cells (HL-1 and HEK293 cells) expressing fluorescently tagged ion channels
Comparison
Jasplakinolide treatment and C-terminal… vs Wild type KCNQ1-KCNE1 complexes and untreated…
Design
Preclinical
Authors
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KCNQ1-KCNE1 actin interaction lost in LQT mutation; hypothesis-generating for channel stabilization without clinical implications yet.
KCNQ1-KCNE1 potassium channel complexes interact intermittently with the actin cytoskeleton via their C-terminal region, an interaction lost in a mutation associated with long QT syndrome.
Mashanov et al. (2009) studied this question.
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