Why the study?
Does a single oral dose of ivabradine 30 mg improve cardiac and systemic haemodynamics compared to propranolol 40 mg or placebo in healthy volunteers?
Does a single oral dose of ivabradine 30 mg improve cardiac and systemic haemodynamics compared to propranolol 40 mg or placebo in healthy volunteers?
Acute administration of ivabradine decreases myocardial oxygen demand similarly to propranolol but without the depressant effect on cardiac function during sympathetic stimulation.
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Ivabradine may be preferable to propranolol when preserving cardiac index during sympathetic activation matters; extends acute hemodynamic comparisons in healthy volunteers.
Joannidès et al. (2005) studied this question.
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