Why the study?
Does the TXA2 receptor antagonist SQ 29,548 reduce ischemia severity in a canine model of pacing-induced ischemia?
Population
Anesthetized, open-chest dogs subjected to left anterior descending coronary artery stenosis and atrial…
Comparison
TXA2 receptor antagonist SQ 29,548 vs Saline
Design
Preclinical
Follow-up
70 minutes
Authors
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Supports TXA2 antagonism for experimental ischemia; leaves open clinical translation from this canine model.
Does the TXA2 receptor antagonist SQ 29,548 reduce ischemia severity in a canine model of pacing-induced ischemia?
In a canine model of pacing-induced ischemia, TXA2 receptor antagonism with SQ 29,548 increased regional myocardial blood flow and reduced S-T elevation, though the ischemic region remained flow-limited.
Grover et al. (1989) studied this question.
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