Why the study?
Does S-145 improve collagen-induced ECG changes and prevent thrombocytopenia in rodents?
Does S-145 improve collagen-induced ECG changes and prevent thrombocytopenia in rodents?
S-145 is a potent, orally active TXA2 receptor antagonist that effectively prevents collagen-induced ECG changes and thrombocytopenia in rodent models.
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S-145 shows potent oral TXA2 antagonism in rodents; leaves open translation to human antithrombotic therapy.
Hori et al. (1989) studied this question.
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