Elevation of intracellular calcium levels contributes to the inhibition of nitric oxide production by atrial natriuretic peptide

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Population

Murine bone marrow-derived macrophages

Comparison

Atrial natriuretic peptide at 10 and 10 mol/L vs Control / C-type natriuretic peptide / Ca2+…

Design

Preclinical

Authors

Discussion

Should not change clinical practice; leaves open ANP's immunomodulatory effects for translational research.

Population

Murine bone marrow-derived macrophages

Intervention

Atrial natriuretic peptide (ANP) at 10(-7) and 10(-6) mol/L

Comparator

Control / C-type natriuretic peptide (CNP) / Ca2+ chelators

Outcome

Intracellular calcium levels and LPS-induced nitric oxide productionsurrogate

This preclinical study demonstrates that ANP inhibits nitric oxide production in macrophages by elevating intracellular calcium levels.

Kiemer et al. (2001) studied this question.

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