Novel Photocleavable Structures I: Synthesis of Hydroxyalkylphenone Analogues Electron-rich Heterocycles

A series of photoinitiating compounds with the general structure ArCOCMe 2 OH, where Ar is 2-furyl (1a), 3-furyl (1b), 2-thienyl (2a), 3-thienyl (2b), 2-pyrrolyl (3a) and 3-pyrrolyl (3b), were prepared.The heterocyclic precursors were substituted by Friedel-Crafts type reaction with isobutyric acid derivatives.Subsequent bromination and hydrolysis gave 1a, 2a and 3b.Derivatives (1b, 2b and 3a) were obtained by reaction of organometallic intermediates of heterocyclic precursors with suitable nitriles or esters.