The study provides the first evidence that neuronal-type Cav 2.1 (P/Q-type) calcium channels are expressed and functionally important for vasoconstriction in renal pre-glomerular vascular smooth muscle.
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Cav 2.1 channels mediate rodent renal vasoconstriction; leaves open human glomerular relevance and therapeutic targeting.
Jensen et al. (2004) studied this question.
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