Key result
Annexin A1 modulates ischemic stroke pathogenesis across inflammation, atherosclerosis, blood-brain barrier protection, and thrombosis.
Why the study?
What is the role of Annexin A1 in the pathogenesis and potential treatment of ischemic stroke?
What is the role of Annexin A1 in the pathogenesis and potential treatment of ischemic stroke?
Answers are grounded in this paper and cite their sources.
Annexin A1 is a key protein involved in multiple protective mechanisms during ischemic stroke, highlighting its potential as a therapeutic target.
Ischemic stroke is a prevalent clinical condition that poses a significant global challenge. Developing innovative strategies to address this issue is crucial. Annexin A1 (ANXA1), a key member of the annexin superfamily, performs various functions, such as inhibiting inflammatory factor release, promoting phagocytosis, and blocking leukocyte migration. Evidence indicates that ANXA1 plays a pivotal role in the pathogenesis of ischemic stroke. The present article reviews involvement of ANXA1 in anti‑atherosclerosis, inflammatory processes, blood‑brain barrier protection, platelet aggregation and anti‑apoptotic mechanisms. The potential applications of ANXA1 in treating ischemic stroke are also explored.
No takes yet. Share an insight, caveat, or question.
Tang et al. (2024) conducted a review in Ischemic stroke. Annexin A1 (ANXA1) was evaluated. Annexin A1 plays a pivotal role in the pathogenesis of ischemic stroke by modulating inflammation, atherosclerosis, blood-brain barrier protection, platelet aggregation, and apoptosis.
Synapse has enriched 10 related papers. Consider them for comparative context: