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Skeletal sarcoplasmic reticulum ryanodine receptor-Ca2+ release channel complex from heavy…
Design
Preclinical
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Cytoplasmic trypsin sensitivity indicates distinct channel domains; leaves open roles in human Ca2+ dysregulation pending mammalian validation.
Trypsin digestion of the skeletal SR Ca2+ release channel reveals distinct structural and functional domains, with cytoplasmic but not lumenal sensitivity to proteolytic degradation.
Meissner et al. (1989) studied this question.
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