Summary By means of highly specific typing systems for genetic γ-globulin factors, evidence has been obtained that the human fetus may synthesize small amounts of γG-globulin. A comparison of the Gm(a) and Gm(b) titers of cord sera with the titers of sera from adults suggests that the two genes, Gma and Gmb, do not synthesize the same relative amounts of γ-globulin at different stages of ontogenetic development. Some, but not all, of the maternal anti-Gm's that sediment as 7 S γ-globulin in density gradient experiments are also detectable in the fetal circulation.
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Mårtensson et al. (1965) studied this question.