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Microbiology and ImmunologyVolume 37, Issue 12 p. 917-925 MinireviewFree Access Thymocyte Apoptosis Harutoshi Kizaki, Corresponding Author Harutoshi Kizaki Department of Biochemistry, Tokyo Dental College, Chiba, Chiba, 261 JapanAddress correspondence to Dr. Harutoshi Kizaki, Department of Biochemistry, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba, Chiba 261, Japan.Search for more papers by this authorTakushi Tadakuma, Takushi Tadakuma Department of Microbiology, School of Medicine, Keio University, Shinjuku-ku, Tokyo, 160 JapanSearch for more papers by this author Harutoshi Kizaki, Corresponding Author Harutoshi Kizaki Department of Biochemistry, Tokyo Dental College, Chiba, Chiba, 261 JapanAddress correspondence to Dr. Harutoshi Kizaki, Department of Biochemistry, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba, Chiba 261, Japan.Search for more papers by this authorTakushi Tadakuma, Takushi Tadakuma Department of Microbiology, School of Medicine, Keio University, Shinjuku-ku, Tokyo, 160 JapanSearch for more papers by this author First published: December 1993 https://doi.org/10.1111/j.1348-0421.1993.tb01725.xCitations: 12AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abbreviations PKA protein kinase A PKC protein kinase C PTK protein tyrosine kinase SGP sulfated glycoprotein TCDD 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin TCR T cell receptor. References 1Arends, M.J., and Wyllie, A.H. 1991. Apoptosis: mechanism and role in pathology. Int. Rev. Exp. Pathol. 32: 223– 254. CrossrefPubMedWeb of Science®Google Scholar 2Azuma, Y., Onishi, Y., Mizuno, Y., and Kizaki, H. 1993. Synergic stimulation of arabinosylcytosine-induced apoptosis in mouse thymocytes by cyclic AMP. Immunopharmacology (in press). Google Scholar 3Baughman, G., Harrigan, M.T., Campbell, N.F., Nurrish, S.J., and Bourgeois, S. 1991. Genes newly identified as regulated by glucocorticoids in murine thymocytes. Mol. Endocrinol. 5: 637– 644. CrossrefCASPubMedWeb of Science®Google Scholar 4Bettuzzi, S., Troiano, L., Davill, P., Tropea, F., Ingletti, M.C., Grassilli, E., Monti, D., Corti, A., and Franceschi, C. 1991. In vivo accumulation of sulfated glycoprotein 2 mRNA in rat thymocytes upon dexamethasone-induced cell death. Biochem. Biophys. Res. Commun. 175: 810– 815. CrossrefCASPubMedWeb of Science®Google Scholar 5Blackman, M., Kappler, J., and Marrack, P. 1990. The role of the T cell receptor in positive and negative selection of developing T cells. Science 248: 1335– 1341. CrossrefCASPubMedWeb of Science®Google Scholar 6Clarke, A.R., Purdie, C.A., Harrison, D.J., Morris, R.G., Bird, C.C., Hooper, M.L., and Wyllie, A.H. 1993. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362: 849– 852. CrossrefCASPubMedWeb of Science®Google Scholar 7Cohen, J.J., and Duke, R.C. 1984. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J. Immunol. 132: 38– 42. CASPubMedWeb of Science®Google Scholar 8Colbert, R.A., and Young, D.A. 1986. Glucocorticoid-induced messenger ribonucleic acids in rat thymic lymphocytes: rapid primary effects specific for glucocorticoids. Endocrinology 119: 2598– 2605. CrossrefCASPubMedWeb of Science®Google Scholar 9Compton, M.M., and Cidlowski, J.A. 1987. Identification of a glucocorticoid-induced nuclease in thymocytes. J. Biol. Chem. 262: 8288– 8292. CASPubMedWeb of Science®Google Scholar 10Domashenko, A.D., Nazarova, L.F., and Umansky, S.R. 1990. Comparison of the spectra of protein synthesized in mouse thymocytes after irradiation of hydrocortisone treatment. Int. J. Radiat. Biol. 57: 315– 329. CrossrefCASPubMedWeb of Science®Google Scholar 11Dowd, D.R., MacDonald, P.N., Komm, B.S., Haussler, M.R., and Miesfeld, R. 1991. Evidence for early induction of calmodulin gene expression in lymphocytes undergoing glucocorticoid-mediated apoptosis. J. Biol. Chem. 266: 18423– 18426. CASPubMedWeb of Science®Google Scholar 12Evan, G.L., Wyllie, A.H., Gilbert, C.S., Littlewood, T.D., and Land, H. 1992. Induction of apoptosis in fibroblasts by c-myc protein. Cell 69: 119– 128. CrossrefCASPubMedWeb of Science®Google Scholar 13Festenstein, H. 1973. Immunogenetic and biological aspects of vivo lymphocyte allotransformation (MLR) in the mouse. Transplant. Rev. 15: 62– 88. Wiley Online LibraryPubMedWeb of Science®Google Scholar 14Fesus, L., Thomazy, V., and Falus, A. 1987. Induction and activation of tissue transglutaminase during programmed cell death. FEBS Lett. 224: 104– 108. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar 15Fowlkes, B.J., and Pardoll, D.M. 1989. Molecular and cellular events of T cell development. Adv. Immunol. 44: 207– 264. CrossrefCASPubMedWeb of Science®Google Scholar 16Grassilli, E., de Prati, C., Monti, D., Troiano, L., Menegazzi, M., Barbieri, D., Franceschi, D., and Suzuki, H. 1992. Studies of the relationship between cell proliferation and cell death II. Early gene expression during concanavalin A-induced proliferation or dexamethasone-induced apoptosis of rat thymocytes. Biochem. Biophys. Res. Commun. 188: 1261– 1266. CrossrefCASPubMedWeb of Science®Google Scholar 17Itoh, N., Yonehara, S., Ishii, A., Yonehara, M., Mizushima, S., Sameshima, M., Hase, A., Seto, Y., and Nagata, S. 1991. The polypeptide encoded by the cDNA for human surface antigen Fas can mediate apoptosis. Cell 66: 233– 243. CrossrefCASPubMedWeb of Science®Google Scholar 18Iwata, M., Hanaoka, S., and Sato, K. 1991. Rescue of thymocytes and T cell hybridomas from glucocorticoid-induced apoptosis by stimulation via the T cell receptor/CD3 complex: a possible in vitro model for positive selection of the T cell repertoire. Eur. J. Immunol. 21: 643– 648. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar 19Jacobson, M.D., Burne, J.F., King, M.P., Miyashita, T., Reed, J.C., and Raff, M.C. 1993. Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA. Nature 361: 365– 369. CrossrefCASPubMedWeb of Science®Google Scholar 20Kappler, J.W., Roehm, N., and Marrack, P. 1987. T cell tolerance by clonal elimination in the thymus. Cell 49: 273– 280. CrossrefCASPubMedWeb of Science®Google Scholar 21Kappler, J.W., Wade, T., White, J., Kushnir, E., Blackman, M., Bill, J., Boehm, N., and Marrack, P. 1987. A T cell receptor Vβ segment that imparts reactivity to a class II major histocompatibility complex product. Cell 49: 263– 271. CrossrefCASPubMedWeb of Science®Google Scholar 22Kappler, J.W., Staerz, U., White, J., and Marrack, P. 1988. Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex. Nature 332: 35– 40. CrossrefCASPubMedWeb of Science®Google Scholar 23Kerr, J. F. R., Wyllie, A.H., and Currie, A.R. 1972. A basic biological phenomenon with wide-ranging implication in tissue kinetics. Br. J. Cancer 26: 239– 257. CrossrefCASPubMedWeb of Science®Google Scholar 24Kizaki, H., Shimada, H., Ohsaka, F., and Sakurada, T. 1988. Adenosine, deoxyadenosine, and deoxyguanosine induce DNA cleavage in mouse thymocytes. J. Immunol. 141: 1652– 1657. CASPubMedWeb of Science®Google Scholar 25Kizaki, H., Tadakuma, T., Odaka, C., Muramatsu, J., and Ishimura, Y. 1989. Activation of a suicide process of thymocytes through DNA fragmentation by calcium ionophores and phorbol esters. J. Immunol. 143: 1790– 1794. CASPubMedWeb of Science®Google Scholar 26Kizaki, H., Suzuki, H., Tadakuma, T., and Ishimura, Y. 1990. Adenosine receptor-mediated accumulation of cyclic AMP-induced T-lymphocyte death through internucleosomal DNA cleavage. J. Biol. Chem. 265: 5280– 5284. CASPubMedWeb of Science®Google Scholar 27Kizaki, H., Nakada, S., Ohnishi, Y., Azuma, Y., Mizuno, Y., and Tadakuma, T. 1993. Tumor necrosis factor-α enhances cAMP-induced programmed cell death in mouse thymocytes. Cytokine (in press). Google Scholar 28Korsmyer, S.J. 1992. Bcl-2: a repressor of lymphocyte death. Immunol. Today 13: 285– 288. CrossrefPubMedWeb of Science®Google Scholar 29Lowe, S.W., Schmitt, E.M., Smith, S.W., Osborne, B.A., and Jacks, T. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362: 847– 849. CrossrefCASPubMedWeb of Science®Google Scholar 30MacDonald, H.R., Schneider, R., Lees, R.K., Howe, R.C., Acha-Orbea, H., Festenstein, H., Zinkernagel, R.M., and Hengartner, H. 1988. T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa-encoded antigens. Nature 332: 40– 45. CrossrefCASPubMedWeb of Science®Google Scholar 31MacDonald H.R., and Lees, R.K. 1990. Programmed death of autoreactive thymocytes. Nature 343: 642– 644. CrossrefCASPubMedWeb of Science®Google Scholar 32McConkey, D.J., Hartzell, P., Jondal, M., and Orrenius, S. 1989. Inhibition of DNA fragmentation in thymocytes and isolated thymocyte nuclei by agents that stimulate protein kinase C. J. Biol. Chem. 264: 13399– 13402. CASPubMedWeb of Science®Google Scholar 33McConkey, D.J., Hartzell, S.C., Chow, S.C., Orrenius, S., and Jondal, M. 1990. Interleukin 1 inhibits T cell receptor-mediated apoptosis in immature thymocytes. J. Biol. Chem. 265: 3009– 3011. CASPubMedWeb of Science®Google Scholar 34McConkey, D.J., Orrenius, S., and Jondal, M. 1990. Agents that elevate cAMP stimulate DNA fragmentation in thymocytes. J. Immunol. 145: 1227– 1230. CASPubMedWeb of Science®Google Scholar 35McConkey, D.J., Orrenius, S., and Jondal, M. 1993. Cyclic AMP potentiates glucocorticoid-induced endogenous endonuclease activation in thymocytes. FASEB J. 7: 580– 585. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar 36Migliorati, G., Nicoletti, I., Pagliacci, M.C., D'Adamio, L., and Riccardi, C. 1993. Interleukin-4 protects double-negative and CD4 single-positive thymocytes from dexamethasone-induced apoptosis. Blood 81: 1352– 1358. CASPubMedWeb of Science®Google Scholar 37Nakayama, K., and Loh, D.Y. 1992. No requirement for p56lck in the antigen-stimulated clonal deletion of the thymocytes. Science 257: 94– 96. CrossrefCASPubMedWeb of Science®Google Scholar 38Nelpovich, P.A., Nikonova, L.V., and Umansky, S.R. 1988. Inhibition of poly(ADP-ribose) polymerase as a possible reason for activation of Ca2+/Mg2+- dependent endonuclease in thymocytes of irradiated rats. Int. J. Radiat. Biol. 53: 749– 765. CrossrefWeb of Science®Google Scholar 39Nieto, M.A., and Lopez-Rivas, A. 1989. IL-2 protects T lymphocytes from glucocorticoid-induced DNA fragmentation and cell death. J. Immunol. 143: 4166– 4170. CASPubMedWeb of Science®Google Scholar 40Ojeda, F., Guarda, M.I., Maldonado, C., and Folch, H. 1990. Protein kinase-C involvement in thymocyte apoptosis induced by hydrocortisone. Cell. Immunol. 125: 535– 539. CrossrefCASPubMedWeb of Science®Google Scholar 41Onishi, Y., Azuma, Y., Sato, Y., Mizuno, Y., Tadakuma, T., and Kizaki, H. 1993. Topoisomerase inhibitors induce apoptosis in thymocytes. Biochim. Biophys. Acta 1175: 147– 154. CrossrefCASPubMedWeb of Science®Google Scholar 42Owens, G.P., Hahn, W.E., and Cohen, J.J. 1991. Identification of mRNAs associated with programmed cell death in immature thymocytes. Mol. Cell. Biol. 11: 4177– 4188. CrossrefCASPubMedWeb of Science®Google Scholar 43Peitsch, M.C., Polzar, B., Stephan, H., Crompton, T., MacDonald, H.R., Mannherz, G.H., and Tschopp, J. 1993. Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death). EMBO J. 12: 371– 377. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar 44Pullen, A., Marrack, P., and Kappler, J.W. 1988. The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens. Nature 335: 796– 801. CrossrefCASPubMedWeb of Science®Google Scholar 45Salaiin, J., Bandeira, A., Khazaal, I., Calman, F., Coltey, M., Coutinko, A., and Le Douarin, N.M. 1990. Thymic epithelium tolerizes for histocompatibility antigens. Science 247: 1471– 1474. CrossrefPubMedWeb of Science®Google Scholar 46Sentman, C.L., Shutter, J.R., Hockenbery, D., Kanagawa, O., and Korsmeyer, S.J. bcl-2 inhibits multiple forms of apoptosis but not nagative selection in thymocytes. Cell 67: 879– 888. Google Scholar 47Shaw, P., Bovey, R., Tardy, S., Sahli, R., Sordat, B., and Costa, J. 1992. Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc. Natl. Acad. Sci. U. S. A. 89: 4495– 4499. CrossrefCASPubMedWeb of Science®Google Scholar 48Shi, Y., Sahai, B.M., and Green, D.R. 1989. Cyclosporine A inhibits activation-induced cell death in T-cell hybridomas and thymocytes. Nature 339: 625– 626. CrossrefCASPubMedWeb of Science®Google Scholar 49Shi, Y., Bissonnette, R.P., Parfrey, N., Szalay, M., Kubo, R.T., and Green, D.R. 1991. In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes. J. Immunol. 146: 3340– 3346. CASPubMedWeb of Science®Google Scholar 50Smeyne, R.J., Vendrell, M., Hayward, M., Baker, S.J., Miao, G.G., Schilling, K., Robertson, L.M., Curran, T., and Morgan, J.I. 1993. Continuous c-fos expression precedes programmed cell death in vivo. Nature 363: 166– 169. CrossrefCASPubMedWeb of Science®Google Scholar 51Smith, C.A., Williams, G.T., and Kingston, R. 1989. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic culture. Nature 337: 181– 184. CrossrefCASPubMedWeb of Science®Google Scholar 52Speiser, D.E., Schneider, R., Hengartner, H., MacDonald, H.R., and Zinkernagel, R.M. 1989. Clonal deletion of self-reactive T cells in irradiation bone marrow chimeras and neonatally tolerance mice. J. Exp. Med. 170: 595– 600. CrossrefCASPubMedWeb of Science®Google Scholar 53Sprent, J., Lo, D., Gao, E.K., and Ron, Y. 1988. T cell selection in the thymus. Immunol. Rev. 101: 173– 190. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar 54Suzuki, K., Tadakuma, T., and Kizaki, H. 1991. Modulation of thymocyte apoptosis by isoproterenol and prostaglandin E2. Cell. Immunol. 134: 235– 240. CrossrefCASPubMedWeb of Science®Google Scholar 55Tadakuma, T., Kizaki, H., Odaka, C., Kubota, R., Ishimura, Y., Yagita, H., and Okumura, K. 1990. CD 4+CD8+ thymocytes are susceptible to DNA fragmentation induced by phorbol ester, calcium ionophore and anti-CD3 antibody. Eur. J. Immunol. 20: 779– 784. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar 56von Boehmer, H., Teh, H.S., and Kisielow, P. 1989. The thymus selects the useful, neglects the useless and destroys the harmful. Immunol. Today 10: 57– 61. CrossrefPubMedWeb of Science®Google Scholar 57Voris, B.P., and Young, D.A. 1981. Glucocorticoid-induced proteins in rat thymus cells. J. Biol. Chem. 256: 11319– 11329. CASPubMedWeb of Science®Google Scholar 58Watanabe-Fukunaga, R., Brannan, D.I., Copeland, N.G., Jenkins, N.A., and Nagata, S. 1992. Lympho-proliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356: 314– 317. CrossrefCASPubMedWeb of Science®Google Scholar 59Wyllie, A.H., Kerr, J. F. R., and Curie, A.R. 1980. Cell death: the significance of apoptosis. Int. Rev. Cytol. 68: 251– 306. CrossrefCASPubMedGoogle Scholar 60Wyllie, A.H. 1980. Glucocorticoid-induced thymocyte apoptosis is associated with endonuclease activation. Nature 284: 555– 556. CrossrefCASPubMedWeb of Science®Google Scholar Citing Literature Volume37, Issue12December 1993Pages 917-925 ReferencesRelatedInformation
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