What question did this study set out to answer?

To evaluate the potential of recombinant human interleukin-7 (rhIL-7) as an immunostimulatory therapy to reverse lymphocyte dysfunctions in septic shock.

October 11, 2012The Journal of ImmunologyOpen Access

IL-7 Restores Lymphocyte Functions in Septic Patients

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Authors

FVFabienne VenetUniversité Claude Bernard Lyon 1 AFAnne‐Perrine ForayHospices Civils de Lyon AVAstrid Villars-MéchinHospices Civils de Lyon

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Implication

Preclinical study demonstrates that recombinant IL-7 restores lymphocyte functions in septic shock patients, highlighting its therapeutic potential for sepsis-induced immune dysfunction.

Key Points

To evaluate the potential of recombinant human interleukin-7 (rhIL-7) as an immunostimulatory therapy to reverse lymphocyte dysfunctions in septic shock.
Quantified circulating IL-7 and soluble CD127 in plasma, alongside cellular CD127 expression on CD4(+) and CD8(+) T lymphocytes from septic shock patients and healthy volunteers.
Evaluated lymphocyte proliferation, IFN-γ production, STAT5 phosphorylation, and Bcl-2 induction ex vivo following T-cell stimulation with or without rhIL-7.
Circulating IL-7 levels and cellular and soluble CD127 receptor expression were not markedly altered and remained responsive to activation in septic patients.
Ex vivo treatment with rhIL-7 significantly restored CD4(+) and CD8(+) lymphocyte proliferation, IFN-γ production, STAT5 phosphorylation, and Bcl-2 induction after cellular stimulation.

Cite This Study

Venet et al. (2012) studied this question.

synapsesocial.com/papers/6a87ec5602f504243ce96f73 https://doi.org/10.4049/jimmunol.1202062

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Implication

Preclinical study demonstrates that recombinant IL-7 restores lymphocyte functions in septic shock patients, highlighting its therapeutic potential for sepsis-induced immune dysfunction.

IL-7 Restores Lymphocyte Functions in Septic Patients

Discussion

Member takes

Implication

Key Points

Cite This Study

IL-7 Restores Lymphocyte Functions in Septic Patients

Discussion

Member takes

Implication

Key Points

Cite This Study

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