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In vitro study demonstrates that topoisomerase inhibitors prevent mAMSA-induced DNA double-strand breaks in mouse mastocytoma nuclei, indicating drug intercalation stimulates topoisomerase II...
Evidence is presented that the topoisomerase inhibitors novobiocin and coumermycin inhibit the production of double-strand breaks in mouse mastocytoma cell nuclear DNA by the anticancer drug 4'[(9-acridinyl)amino]-methanesulphon-m-anisidide (mAMSA). Novobiocin did not inhibit resealing of DNA breaks induced by mAMSA. It is suggested that mAMSA intercalation into DNA induces the action of a type II topoisomerase. mAMSA and oAMSA were equally effective in breaking the DNA in isolated nuclei.
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Marshall et al. (1983) studied this question.
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