Why the study?
Does spironolactone 50 mg once daily reduce blood pressure and arterial stiffness in essential hypertensive patients uncontrolled on enalapril 10 mg?
Does spironolactone 50 mg once daily reduce blood pressure and arterial stiffness in essential hypertensive patients uncontrolled on enalapril 10 mg?
Spironolactone 50 mg daily is effective at reducing blood pressure and arterial stiffness in hypertensive patients inadequately controlled on enalapril.
May support spironolactone add-on in enalapril-uncontrolled hypertension; hypothesis-generating and requires randomized confirmation before practice change.
Background: In previous studies we demonstrated that spironolactone 50 mg OD, added in hypertensive patients who do not normalize pressure with enalapril 10 mg in the morning, after 3 months reduces pressure and reduces arterial stiffness.
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Mario Bendersky (2021) studied this question.
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