Why the study?
Does pregnancy alter the metabolic clearance rate of angiotensin II in sheep?
Does pregnancy alter the metabolic clearance rate of angiotensin II in sheep?
The reduced pressor response to angiotensin II in pregnancy is not caused by increased metabolic clearance or lower plasma concentrations.
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Blunted pressor response to angiotensin II in pregnant sheep is independent of metabolic clearance rate; leaves open mechanisms of gestational vascular refractoriness.
Naden et al. (1985) studied this question.
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