Why the study?
Does priming with COMP-Ang1 improve the engraftment and neovascularization potential of G-CSF mobilized peripheral blood stem cells in ischemic models?
Population
Peripheral blood stem cells mobilized with G-CSF (PBSCs) from acute myocardial infarction patients…
Comparison
Short-term priming ofPBSCs with cartilage… vs UnprimedPBSCs or naïve peripheral blood…
Design
Preclinical
Authors
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COMP-Ang1 priming of PBSCs merits clinical translation studies; leaves open whether benefits extend to AMI patients.
Does priming with COMP-Ang1 improve the engraftment and neovascularization potential of G-CSF mobilized peripheral blood stem cells in ischemic models?
Short-term priming of mobilized peripheral blood stem cells with COMP-Ang1 enhances their endothelial differentiation, adhesiveness, and engraftment in ischemic models, suggesting a potential strategy to improve cell therapy efficacy.
Kim et al. (2009) studied this question.
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