Why the study?
What are the autonomic mechanisms (baroreceptor sensitivity, sympathetic withdrawal, parasympathetic activity) underlying vasovagal syncope during orthostasis?
Population
35 patients undergoing 60 degrees head-up tilt testing, including 18 who experienced vasovagal syncope and…
Comparison
60 degrees head-up tilt testing vs Patients who tolerated tilt for 45 min without…
Design
Cohort
Follow-up
45 minutes (duration of tilt test)
Authors
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Links sympathetic withdrawal to vasovagal presyncope hemodynamics; hypothesis-generating and requires prospective trials before clinical adoption.
What are the autonomic mechanisms (baroreceptor sensitivity, sympathetic withdrawal, parasympathetic activity) underlying vasovagal syncope during orthostasis?
Vasodilatation and bradycardia during vasovagal presyncope appear to be driven more by withdrawal of sympathetic activity than by increased parasympathetic cardiac activity.
Jardine et al. (1998) studied this question.
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