Why the study?
Does intravenous lidocaine alter systemic circulation and hepatic blood flow in healthy volunteers?
Does intravenous lidocaine alter systemic circulation and hepatic blood flow in healthy volunteers?
Intravenous lidocaine increases hepatic blood flow and cardiac output in healthy volunteers, driven by a concentration-dependent reduction in splanchnic vascular resistance.
Healthy volunteer data should not change practice; leaves open translation to surgical or critically ill patients.
Twelve healthy young volunteers were studied before and during intravenous administration of lidocaine at a dose rate of 2 or 4 mg/min. Five additional volunteers, who did not receive lidocaine solution but were given the same amount of physiological saline, were studied in the same manner. Heart rate, cardiac output, mean arterial blood pressure, mean right atrial blood pressure, estimated hepatic blood flow and plasma concentration of lidocaine were measured repeatedly. The results showed an increase in heart rate, cardiac output and mean arterial blood pressure, the latter two variables in relation to the plasma concentration of lidocaine. The estimated hepatic blood flow increased, partly as a result of the reduction of splanchnic vascular resistance and partly due to the stimulation of cardiac output. The decrease in splanchnic vascular resistance was proportional to the plasma concentration of lidocaine.
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Lars Wiklund (1977) studied this question.
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