Review on lymphoma and deregulated signaling pathways

Since the incidence of cancer is increasing worldwide, there is an urgent need for more successful therapies. Here, we focused on a literature review regarding lymphoma and deregulated pathways that are hallmarks of lymphoma development. Among others, PI3K/AKT, NF-ĸB and JAK/STAT pathways are the most common deregulated ones. These signaling pathways are crucial for numerous cellular processes and possible deregulation can mainly lead to uncontrolled cell division and inhibition of apoptosis. A literature review was performed by using databases including PubMed, PubMed Central and Google Scholar from where the most recent and valuable studies were selected.