Why the study?
Diabetes mellitus is an independent risk factor for atrial fibrillation, but the specific role of atrial cardiomyocyte electrical remodeling requires synthesis to inform antiarrhythmic drug management.
This review highlights the mechanisms of electrical remodeling in the atria of diabetic patients, providing a theoretical basis for the use of antiarrhythmic drugs in this population.
Does not yet alter AF management in diabetes; leaves open targeted ion channel therapies for prospective validation.
Atrial fibrillation (AF) is one of the most common arrhythmias in medical practice. Diabetes mellitus (DM) is one of the independent risk factors for atrial fibrillation. The increased morbility of atrial fibrillation in diabetes mellitus is related to both structural and electrical remodeling of atrium. Based on studies of atrial electrophysiological changes in diabetes mellitus, this article focuses on the electrical remodeling of atrial cardiomyocytes, including remodeling of sodium channels, calcium channels, potassium channels and other channels, to provide the basis for the clinical management of antiarrhythmic drugs in diabetic patients with atrial fibrillation.
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Qian et al. (2023) studied this question.
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