Lower early mortality and risk prediction improvement of obesity after acute pulmonary embolism: results from a multicenter cohort analysis with external validation

Figures

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  Figure 1. Clinical factors independently associated with the 30-day all-cause mortality after acute pulmonary embolism. Obesity is defined by a body mass index of ≥30 kg/m2 according to the WHO definition. aCancer is considered active when at least one of the following 3 conditions is met: (1) the patient has received a potentially noncurative treatment for cancer (case in particular of so-called palliative chemotherapy); (2) the evolution shows recurrence or progression of the cancer under treatment; and (3) cancer treatment is ongoing. Covariates used for the multivariate adjustment are given in Supplementary Table S7. CAD, coronary artery disease; PE, pulmonary embolism; SBP, systolic blood pressure; OR, odds ratio.

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  Figure 2. Cumulative frequencies of acute pulmonary embolism all-cause death at 30 days and associated pulmonary reperfusion strategies according to the European Society of Cardiology (ESC) prognosis risk category (P values, unadjusted comparison).

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  Figure 3. Secondary outcomes at 30 days and 6 months between patients with and without obesity after acute pulmonary embolism. Obesity is defined by a body mass index of ≥30 kg/m2 according to the WHO definition. CRNM, clinically relevant nonmajor; OR, odds ratio; VTE, venous thromboembolism.

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  Figure 4. Cox model–derived adjusted curves for the primary outcome, all-cause death at 6 months, between patients with and without obesity after acute pulmonary embolism. Obesity is defined by a body mass index of ≥30 kg/m2 according to the WHO definition. Covariates used for the multivariate adjustment are given in Supplementary Table S7. HR, hazard ratio.

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  Figure 5. External validation of the primary outcomes, all-cause death at 30 days and 6 months, between patients with and without obesity after acute pulmonary embolism recorded in the RIETE registry (n = 35,796). OR, odds ratio.