What question did this study set out to answer?

To develop and validate a clinical scoring tool (InterTAK Diagnostic Score) capable of distinguishing Takotsubo syndrome from acute coronary syndrome during acute presentation.

December 7, 2016European Journal of Heart FailureOpen Access

A Novel Clinical Score (InterTAK Diagnostic Score) to Differentiate Takotsubo Syndrome from Acute Coronary Syndrome: Results from the International Takotsubo Registry

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Why the study?

Does the InterTAK Diagnostic Score accurately differentiate Takotsubo syndrome from acute coronary syndrome in the acute stage?

Population

1,053 patients from the International Takotsubo Registry and a Zurich hospital.

Design

Cohort

Authors

JGJelena R. GhadriCardiac Imaging VCVictoria L. CammannGeneral Cardiology SJStjepan JurisicElectrophysiology

Discussion

Member takes

Implication

The InterTAK Diagnostic Score provides a highly sensitive and specific clinical tool to differentiate Takotsubo syndrome from acute coronary syndrome in the acute setting.

Key Points

To develop and validate a clinical scoring tool (InterTAK Diagnostic Score) capable of distinguishing Takotsubo syndrome from acute coronary syndrome during acute presentation.
Multiple logistic regression was performed using a derivation cohort of patients with Takotsubo syndrome (n = 218) from the International Takotsubo Registry and acute coronary syndrome (n = 436) to construct a seven-variable score (NCT0194762).
The clinical score was subsequently tested in an independent validation cohort consisting of patients with Takotsubo syndrome (n = 173) and acute coronary syndrome (n = 226).
In the derivation cohort, the InterTAK score achieved an AUC of 0.971 (95% CI 0.96–0.98); a cutoff of 40 points yielded 89% sensitivity and 91% specificity, with scores ≥50 and ≤31 correctly diagnosing ~95% of TTS and ACS cases, respectively.
In the independent validation cohort, the score maintained strong diagnostic performance with an AUC of 0.901 (95% CI 0.87–0.93).

Structured PICO

Does the InterTAK Diagnostic Score accurately differentiate Takotsubo syndrome from acute coronary syndrome in the acute stage?

Population

1,053 patients (derivation cohort: 218 with Takotsubo syndrome [TTS] and 436 with acute coronary syndrome [ACS]; validation cohort: 173 with TTS and 226 with ACS) from the International Takotsubo Registry and a Zurich hospital.

Intervention

InterTAK Diagnostic Score (7 variables: female sex, emotional trigger, physical trigger, absence of ST-segment depression except in lead aVR, psychiatric disorders, neurologic disorders, and QTc prolongation)

Outcome

Diagnostic accuracy (Area under the curve [AUC], sensitivity, and specificity) to distinguish TTS from ACSsurrogate

The InterTAK Diagnostic Score provides a highly sensitive and specific clinical tool to differentiate Takotsubo syndrome from acute coronary syndrome in the acute setting.

Cite This Study

Ghadri et al. (2016) studied this question.

synapsesocial.com/papers/6a87f6ea010a27dee476e945 https://doi.org/10.1002/ejhf.683

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Implication

The InterTAK Diagnostic Score provides a highly sensitive and specific clinical tool to differentiate Takotsubo syndrome from acute coronary syndrome in the acute setting.

A Novel Clinical Score (InterTAK Diagnostic Score) to Differentiate Takotsubo Syndrome from Acute Coronary Syndrome: Results from the International Takotsubo Registry

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

A Novel Clinical Score (InterTAK Diagnostic Score) to Differentiate Takotsubo Syndrome from Acute Coronary Syndrome: Results from the International Takotsubo Registry

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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