Why the study?
Does therapeutic anticoagulation resolve large aortic valve vegetations and prevent recurrent embolic events in patients with antiphospholipid syndrome?
Does therapeutic anticoagulation resolve large aortic valve vegetations and prevent recurrent embolic events in patients with antiphospholipid syndrome?
Therapeutic anticoagulation may be an effective and safe alternative to high-risk surgical intervention for managing large non-bacterial aortic valve vegetations in antiphospholipid syndrome.
Anticoagulation may resolve large vegetations without recurrence in APS; hypothesis-generating and leaves open role versus surgery.
Non-bacterial thrombotic endocarditis in antiphospholipid syndrome presents a management dilemma. Large mobile valvular lesions pose an increased risk of stroke and arterial embolization. However, surgical excision or valve replacement in such patients carries high morbidity and mortality, while anticoagulation alone has limited data. We describe two patients with antiphospholipid syndrome presenting with neurologic events and large non-bacterial aortic valve vegetations. Both patients were successfully managed with anticoagulation and demonstrated rapid dissolution of lesions without evidence of recurrent embolic events. We provide a literature review describing additional cases managed with anticoagulation with dissolution of valvular lesions over time. Our cases further support the efficacy and safety of anticoagulation in patients with antiphospholipid syndrome and non-bacterial thrombotic endocarditis in the context of arterial embolization.
No takes yet. Share an insight, caveat, or question.
Yuriditsky et al. (2018) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: