Why the study?
To develop and validate three nomograms incorporating the advanced lung cancer inflammation index to aid in predicting the risk of CAD and CAC.
Can nomograms based on the advanced lung cancer inflammation index (ALI) predict the risk of coronary artery disease and calcification in patients with suspected CAD?
Can nomograms based on the advanced lung cancer inflammation index (ALI) predict the risk of coronary artery disease and calcification in patients with suspected CAD?
Nomograms incorporating the advanced lung cancer inflammation index (ALI) provide moderate predictive accuracy for identifying coronary artery disease and calcification in patients undergoing coronary CTA.
ALI nomograms may aid CAD risk stratification on CTA; leaves open prospective validation versus standard predictors.
Aim To develop and validate 3 nomograms incorporating the advanced lung cancer inflammation index (ALI) that can aid in predicting the risk of coronary artery disease (CAD) and coronary artery calcification (CAC). Methods The study enrolled 562 consecutive patients with suspected CAD who underwent coronary computed tomographic angiography between September 2015 and June 2017. Independent risk factors for CAD, CAC, and CAD with CAC were identified via univariate and multivariate analysis, and nomograms were established based on the independent predictors identified. The area under the curve (AUC), calibration curve, and decision curve analysis were used to evaluate the nomograms. Correlations between ALI and other clinical indicators were examined via Spearman correlation analysis. Results In total, 549 patients with suspected CAD who underwent coronary computed tomographic angiography were included. Male sex, hypertension, diabetes, dyslipidemia, ischemic stroke, and ALI were independent predictors of both CAD and CAC. Male sex, hypertension, diabetes, dyslipidemia, and ALI were also identified as independent predictors of CAD with CAC. The AUC values for the nomograms developed using these risk factors were 0.739 (95% confidence interval [CI], 0.693-0.785), 0.728 (95% CI, 0.684-0.772), and 0.717 (95% CI 0.673-0.761), respectively. ALI was negatively correlated with neutrophil-to-lymphocyte ratio and CAC score and positively correlated with serum albumin levels and body mass index (all P < .05). Conclusions ALI is an independent predictor of CAD, CAC, and CAD with CAC. Our ALI-based nomograms can provide accurate and individualized risk predictions for patients with suspected CAD.
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Fan et al. (2021) studied this question.
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