May 1, 1976Circulation ResearchOpen Access

Depression of atrioventricular sensitivity in the dog by successive brief bursts of vagal stimulation.

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Why the study?

Does successive vagal stimulation alter atrioventricular conduction time in dogs?

Population

Dogs (preclinical model)

Comparison

Successive single vagal stimulations separated… vs First vagal stimulation vs. second vagal…

Design

Preclinical

Authors

MPMartin PjBAE Systems (United Kingdom)

Discussion

Member takes

Implication

Indicates vagal desensitization of canine AV conduction; leaves open any human relevance or therapeutic implications.

Structured PICO

Does successive vagal stimulation alter atrioventricular conduction time in dogs?

Population

Dogs (preclinical model)

Intervention

Successive single vagal stimulations separated by 2-60 seconds

Comparator

First vagal stimulation vs. second vagal stimulation

Outcome

Peak change in atrioventricular conduction time (deltaAV)surrogate

Successive vagal stimulations in dogs result in a time- and amplitude-dependent depression of atrioventricular sensitivity, likely due to changes in receptor responsiveness or acetylcholine inactivation.

Cite This Study

Martin Pj (1976) studied this question.

synapsesocial.com/papers/6a87f96cb0d802598bf4c8f8 https://doi.org/10.1161/01.res.38.5.448

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May 1, 1976Circulation ResearchOpen Access

Depression of atrioventricular sensitivity in the dog by successive brief bursts of vagal stimulation.

View Full Paper

Ask AI

Bookmark

Why the study?

Does successive vagal stimulation alter atrioventricular conduction time in dogs?

Population

Dogs (preclinical model)

Comparison

Successive single vagal stimulations separated… vs First vagal stimulation vs. second vagal…

Design

Preclinical

Authors

MPMartin PjBAE Systems (United Kingdom)

Discussion

Member takes

Implication

Indicates vagal desensitization of canine AV conduction; leaves open any human relevance or therapeutic implications.

Structured PICO

Does successive vagal stimulation alter atrioventricular conduction time in dogs?

Population

Dogs (preclinical model)

Intervention

Successive single vagal stimulations separated by 2-60 seconds

Comparator

First vagal stimulation vs. second vagal stimulation

Outcome

Peak change in atrioventricular conduction time (deltaAV)surrogate

Cite This Study

Martin Pj (1976) studied this question.

synapsesocial.com/papers/6a87f96cb0d802598bf4c8f8 https://doi.org/10.1161/01.res.38.5.448

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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