Population
Reserpinized dogs
Comparison
Simultaneous stimulation of both right and left… vs Predicted atrial rate based on additive effects…
Design
Preclinical
Authors
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Does not inform human vagal therapies; extends additive acetylcholine model to bilateral stimulation in canines.
Demonstrates that the effects of acetylcholine released by right and left vagal nerves on atrial rate are additive in a canine model.
Hondeghem et al. (1975) studied this question.
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