Why the study?
Does the timing of repetitive vagal stimulation affect atrial contraction in anesthetized dogs?
Population
Anesthetized dogs
Design
Preclinical
Authors
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May guide vagal timing in canine models; leaves open translation to human neuromodulation or arrhythmia therapies.
Does the timing of repetitive vagal stimulation affect atrial contraction in anesthetized dogs?
The timing of vagal stimulation within the cardiac cycle significantly influences its negative inotropic effect on atrial contraction in dogs, suggesting rapid acetylcholine hydrolysis and phase-dependent sensitivity.
Martin et al. (1983) studied this question.
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