Why the study?
The article aims to correct misunderstandings regarding calcium, myosin binding protein-C, and hypertrophic cardiomyopathy in basic cardiac muscle function.
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Design
Review
Advances theoretical models of actomyosin kinetics in HCM; leaves open experimental validation before any clinical relevance.
In an attempt to correct misunderstandings this article brings together the observations on Calcium, Myosin Binding Protein-C and Hypertrophic Cardiomyopathy in the basic function of cardiac muscle. A finding of many years ago is reiterated in a novel enzyme kinetic format with defined rate limiting step which makes CaATP the apparent substrate of the actomyosin cross-bridge. The relationship of these kinetics to recent observations on disruption of myosin binding protein-C is described along with how this bears on the understanding of the related cardiomyopathies.
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Gerry A. Smith (2019) studied this question.
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