What does this research mean for the field?

Myosin binding protein C (MyBP-C) governs cardiac sarcomere interactions by simultaneously controlling myosin sequestration on the thick filament and regulating myosin's activation state and access to binding sites on the thin filament. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 20, 2020Journal of Muscle Research and Cell MotilityOpen Access

MyBP-C: one protein to govern them all

View Full Paper

Ask AI

Bookmark

Why the study?

Myosin binding protein C accounts for ~ 40% of all known mutations in hypertrophic cardiomyopathy, warranting a complete understanding of its molecular function in the cardiac sarcomere.

Design

Review

Authors

LHLaurens W.H.J. HelingLeiden University MGMichael A. GeevesHeart Failure / Cardiomyopathy NKNeil M. KadUniversity of Kent

Discussion

Member takes

Implication

Offers mechanistic context for MyBP-C mutations in HCM; leaves targeted therapy development open pending clinical validation.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Heling et al. (2020) studied this question.

synapsesocial.com/papers/6a1be651ea84844e355f2611 https://doi.org/10.1007/s10974-019-09567-1

View Full Paper

Ask AI

Bookmark

MyBP-C: one protein to govern them all

Discussion

Member takes

Implication

Key Points

Cite This Study

MyBP-C: one protein to govern them all

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider