Population
Rat ventricular myocytes, recombinant cMyBP-C fragments, and chemically permeabilized mouse ventricular…
Comparison
RSK activation and adenoviral expression of… vs RSK inhibition, kinase-inactive RSK, or PKA
Design
Preclinical
Authors
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May alter myofilament regulation in animal models; hypothesis-generating for human therapies, requires validation before clinical consideration.
RSK directly phosphorylates cMyBP-C at Ser(282), regulating cardiac myofilament function by reducing calcium sensitivity and accelerating cross-bridge kinetics.
Cuello et al. (2010) studied this question.
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