GSK3β Phosphorylates Newly Identified Site in the Proline-Alanine–Rich Region of Cardiac Myosin–Binding Protein C and Alters Cross-Bridge Cycling Kinetics in Human
Population
Human heart tissue and single membrane-permeabilized human cardiomyocytes
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May enhance sarcomere force kinetics via cMyBP-C; leaves open therapeutic relevance in human disease.
Structured PICO
P
Population
Human heart tissue and single membrane-permeabilized human cardiomyocytes
I
Intervention
Glycogen synthase kinase 3β (GSK3β) treatment
O
Outcome
Identification of novel phosphorylation sites on cMyBP-C and effect on maximal rate of tension redevelopmentsurrogate
GSK3β phosphorylates a newly identified site (Ser133) on cMyBP-C, increasing the kinetics of force development and suggesting a novel mechanism for regulating sarcomere kinetics.
Cite This Study
Kuster et al. (2013) studied this question.