Population
Recombinant human and murine cardiac myosin binding protein-C (cMyBP-C) proteins (C0C2 and C1C2)
Comparison
Treatment with protein kinase A (PKA) vs Without PKA treatment
Design
Preclinical
Authors
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Should not alter clinical management; leaves open the functional impact of these sites on contraction in vivo.
This study identifies novel PKA phosphorylation sites in the M-domain of human and murine cMyBP-C, providing new insights into the molecular regulation of cardiac muscle contraction.
Jia et al. (2010) studied this question.
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