Animal experiment demonstrates surface-concentrated fluoride accumulation across dental tissues in rats, highlighting cementum as a primary mineral reservoir.
This study was undertaken to determine the fluoride distribution in cementum and neighboring hard tissues of the rat after different levels of fluoride administration via the drinking water. Specimens of cementum with underlying dentine and adjacent bone were removed from the distal roots of the first lower molars. The fluoride distribution in each specimen was determined in samples removed sequentially using an abrasive microsampling technique. Fluoride concentrations were highest at or near the surface and decreased towards the interior of cementum, dentine and alveolar bone in both control and experimental groups. With increasing fluoride intake, concentrations increased throughout the tissue. The distribution patterns of fluoride in cementum of contralateral teeth from the same animal were similar. Fluoride concentrations in cementum were higher than those of dentine and alveolar bone.
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Kato et al. (2009) studied this question.
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