What question did this study set out to answer?

To evaluate the function of the hypothalamic-pituitary axis and determine the prevalence of endocrine dysfunction in patients treated with radiotherapy for nasopharyngeal cancer.

December 1, 1975Annals of Internal Medicine

Hypopituitarism After External Irradiation

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Authors

NSN. A. SamaanThe University of Texas System MBM. M. Bakdash JCJesus B. CaderaoThe University of Texas System

Discussion

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Implication

Clinical evaluation reveals high rates of endocrine deficiencies following head and neck radiotherapy, indicating radiation-induced hypopituitarism is underrecognized.

Key Points

To evaluate the function of the hypothalamic-pituitary axis and determine the prevalence of endocrine dysfunction in patients treated with radiotherapy for nasopharyngeal cancer.
Assessed hypothalamic-pituitary axis function in patients who underwent radiotherapy for nasopharyngeal cancer (N=15).
Measured endocrine function utilizing synthetic hypothalamic hormone testing and hormone radioimmunoassays.
Fourteen of 15 patients exhibited evidence of endocrine deficiency following radiotherapy.
Hypothalamic dysfunction occurred in 12 patients, primary pituitary hormone deficiencies occurred in 7 patients, and primary hypothyroidism occurred in 3 patients.

Cite This Study

Samaan et al. (1975) studied this question.

synapsesocial.com/papers/6a87fc86d79ae02bd34dea4e https://doi.org/10.7326/0003-4819-83-6-771

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Implication

Clinical evaluation reveals high rates of endocrine deficiencies following head and neck radiotherapy, indicating radiation-induced hypopituitarism is underrecognized.

Hypopituitarism After External Irradiation

Discussion

Member takes

Implication

Key Points

Cite This Study

Hypopituitarism After External Irradiation

Discussion

Member takes

Implication

Key Points

Cite This Study

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