February 13, 1989FEBS LettersOpen Access

Angiotensinogen production by rat hepatoma cells is stimulated by B cell stimulatory factor 2/interleukin‐6

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Population

Reuber H35 hepatoma cell line

Comparison

B cell stimulatory factor 2/interleukin-6 in the… vs Dexamethasone alone, IL-6 without…

Design

Preclinical

Authors

NINorio ItohKyushu University TMToshie MatsudaKobe Gakuin University RORemiko OhtaniKobe Gakuin University

Discussion

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Implication

Hypothesis-generating for glucocorticoid-dependent IL-6 effects on hepatic angiotensinogen in inflammation; leaves open human cardiovascular relevance.

Structured PICO

Population

Reuber H35 hepatoma cell line

Intervention

B cell stimulatory factor 2/interleukin-6 (IL-6, 50 U/ml) in the presence of 10(-7) M dexamethasone

Comparator

Dexamethasone alone, IL-6 without glucocorticoid, or other cytokines (interleukin-1, interferon-alpha)

Outcome

Angiotensinogen secretionsurrogate

IL-6 acts as a mediator for increased angiotensinogen synthesis in the liver during acute inflammation, requiring the presence of glucocorticoids.

Cite This Study

Itoh et al. (1989) studied this question.

synapsesocial.com/papers/6a87fdf0fa9d1f0cc6582788 https://doi.org/10.1016/0014-5793(89)81150-0

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Implication

Hypothesis-generating for glucocorticoid-dependent IL-6 effects on hepatic angiotensinogen in inflammation; leaves open human cardiovascular relevance.

Angiotensinogen production by rat hepatoma cells is stimulated by B cell stimulatory factor 2/interleukin‐6

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensinogen production by rat hepatoma cells is stimulated by B cell stimulatory factor 2/interleukin‐6

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider