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August 1, 1940Archives of Dermatology

Acute Interstitial Myocarditis Following Administration of Arsphenamines

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Population

Patients developing exfoliative dermatitis following the administration of arsphenamines.

Design

Review

Authors

CBClark E. BrownSanta Barbara Cottage Hospital

Discussion

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Implication

Arsphenamine-related fatal myocarditis is hypothesis-generating; leaves open relevance to modern agents and requires prospective study.

Structured PICO

P
Population
Patients developing exfoliative dermatitis following the administration of arsphenamines.
I
Intervention
Arsphenamines
O
Outcome
Fatal acute cardiac failure and acute interstitial (Fiedler's) myocarditissafety

Arsphenamine administration is associated with a rare but fatal acute interstitial myocarditis, highlighting a severe cardiac toxicity of this historical treatment.

Cite This Study

Clark E. Brown (1940) studied this question.

synapsesocial.com/papers/6a87ff0cce59b4d55bcf0367https://doi.org/10.1001/archderm.1940.01490140076015
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ACUTE INTERSTITIAL MYOCARDITIS1934 · 7 citations
  2. 2THE ARTHUS PHENOMENON1932 · 30 citations
  3. 3SPONTANEOUS INTERSTITIAL MYOCARDITIS IN RABBITS1924 · 45 citations