Evidence is presented that monoamine oxidase is involved in the metabolism of dopamine in brain. Thus 3,4‐dihydroxyphenylacetic acid has been demonstrated to occur in the brains of three species investigated, including man. That this acid was derived from dopamine after oxidative deamination seemed probable as it was found to be localized in the same areas of the brain as dopamine and it disappeared after inhibition of monoamine oxidase with iproniazid. The capacity of this enzyme in brain seemed to be sufficient for the plausible inactivation rate of dopamine in this tissue.
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Evald Rosengren (1960) studied this question.
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