Phenotyping chronic pulmonary aspergillosis by cluster analysis

Chronic pulmonary aspergillosis (CPA) is a complex disorder involving various underlying conditions and risk factors, clinical and radiological features, and natural histories or responses to treatment [1]. Untreated, patients with CPA have ≥50% 5-year mortality [2, 3]. Recently, it was proposed that CPA includes simple aspergilloma, chronic cavitary pulmonary aspergillosis (CCPA) and chronic necrotising pulmonary aspergillosis (CNPA) [1]. Cluster analysis based on clinical and radiological settings does not distinguish any specific phenotype of CPA http://ow.ly/QZq7V Philippe Gegou (INTRASENSE technical and computer support team, Montpellier, France) who enabled us to work on Myrian, the software suite used for the visualisation and post-processing of our medical images. The authors also wish to thank Jeffrey Arsham (an American medical translator working at CHU Poitiers, Poitiers, France) for reviewing and editing the original English language manuscript. Marie France Carette (Service de Radiologie, AP-HP, Hôpital Tenon, Paris, France) and Gilbert Ferriti (Service de Radiologie, CHU Grenoble, Grenoble, France) both radiologists who assisted us with data collection. Jean-Pierre Frat (Service de Réanimation médicale, CHU Poitiers, Poitiers, France) for editing the original manuscript. The following investigators participated in the ACHROSCAN study group: François Laurent, CHU Bordeaux, Bordeaux, France; Boubou Camara and Christophe Pison, CHU Grenoble, Grenoble, France; Catherine Beigelman-Aubry, CHUV Lausanne, Lausanne, Switzerland; Vincent Cottin CHU Lyon, Lyon, France; Patrick Germaud, CHU Nantes, Nantes, France; Anne Bergeron, APHP Paris, Paris, France; Jacques Cadranel, Antoine Khalil and Cécile Toper, APHP, Paris, France; Guillaume Béraud, Pascal Blouin and Cendrine Godet CHU Poitiers, Poitiers, France; Bruno Philippe, CH Pontoise, Pontoise, France. Cendrine Godet, Jacques Cadranel and Anne Bergeron are members of the GREPI (French Group for Research and Education in Respiratory Infectious Diseases).